Regeln of wrinkles — the opinion of cosmetologists, reviews

The characteristics of the composition

Active substance:

  • Hyaluronas Zinci (zinc hyaluronate). Associate formed by the interaction of sodium hyaluronate and zinc chloride.


  • sodium hydroxide (caustic soda, soda lye) is necessary as an emulsifying agent;
  • sodium hyaluronate — increases the viscosity and elasticity of tissues;
  • purified water filler;
  • potassium sorbate — a preservative, allows long time to keep the properties of the drug in an unmodified form;
  • carbopol — structure-forming substance is a thickening agent that adds viscosity;
  • zinc chloride — see «what is affected».

Indications and contraindications

Indicated for the treatment of:

  • demodicosis,
  • seborrheic dermatitis
  • komedonov and papules-pustular acne,
  • rosacea (rosacea),
  • acne vulgaris;
  • for improvement of regeneration after removal of benign tumors of the skin (papillomas, warts, warts), laser correction, cosmetic surgery.


  • hypersensitivity to the drug;
  • burns;
  • tumor;
  • the deep wounds.

What has an effect

Regeln of wrinkles is effective for the simple reason that the composition contains hyaluronic acid.

Hyaluronas Zinci (zinc hyaluronate) has a regenerating, antimicrobial, moisturizing, anti-inflammatory, antimicrobial activity.

Hyaluronic acid is mukopolisaharidnyh polymer required for the intercellular substance. In this formulation is plant high molecular compound.

Hyaluronic acid is involved in:

  • the formation of the dispersion matrix
  • the frame for the cells, which replaces the damaged areas in the tissues, heals wounds,
  • stimulates the proliferation of primary cells of connective tissue
  • increases the activity of defensive cells,
  • improves the formation of new blood vessels, increasing trophic tissue.

After artificially increasing the local amount of hyaluronic acid:

  1. increases the rate of migration of keratinocytes
  2. decreased rate of aging (the epidermis is thickened, and the Horny cell layer becomes thinner),
  3. improves trophic cells
  4. the output of oxidized products of metabolism and free radicals.
  5. increasing protective properties against ultraviolet radiation. Due to such effects are supported by the tone and elasticity of the skin.
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Zinc is a part of many enzyme systems, membranes, and receptors of cells. Normalizes the keratinization and formation of sebum. Increases the speed of building the protein, resulting in an increase in the speed of cell division.

Zinc is an antimicrobial agent for:

  • Streptococcus,
  • Staphylococcus aureus,
  • Escherichia coli and Pseudomonas aeruginosa.

The organisms cause an inflammatory reaction that leads to disruption of metabolism. What affects the recovery of the action potential of cells and the appearance of wrinkles.

By participating in the destruction of bacteria reduces the inhibition of regeneration processes.

Instructions for use of Regitine from wrinkles

Before using the product the skin should be thoroughly cleaned of:

  • sebum,
  • microorganisms
  • dust,
  • cosmetics and everything else.

Applied a uniform thin layer on the skin.

In areas of education wrinkles the drug is rubbed in a circular motion of low intensity.

Repeat procedure 2 times a day for the first week of use. In the morning before applying creams and cosmetics. In the evening before bed. In the ensuing weeks, 1 time a day, better at night, better then the epithelium is restored.

The course can vary from 1 to 3 months. Then make a break for 1 month and can be repeated. The duration of the drug is not limited.

Video: Rules of application

Adverse reactions

Allergic reactions to components of the drug:

  • skin rashes;
  • dermatitis;
  • urticaria;
  • itching;
  • generalized exfoliative dermatitis;
  • angioedema;
  • anaphylactic reaction;
  • anaphylactic shock;
  • angioedema.

Local reactions:

  • feel a slight burning;
  • redness;
  • a feeling of tightness of the skin.

After 2-3 days of application local reactions are. If they don’t disappear, you should consult a dermatologist.

Data on use during pregnancy no.

The pros and cons


  • a wide spectrum of action;
  • adverse reactions occur in a small number of target audience;
  • affordable price;
  • does not change color;
  • does not stain linen;
  • absorbs quickly;
  • easy to use;
  • not addictive;
  • possible to use with other drugs;
  • does not possess photosensitizing properties (you can sunbathe during use).
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  • studied has been the effect on the fetus;
  • quite dry skin. But this is eliminated by the use of moisturizer;
  • effective only upon the ability of stimulation of the regenerative processes.

The opinion of cosmetologists

Cosmetologists perform:

  1. chemical peels,
  2. microdermabrasion,
  3. mesotherapy,
  4. photorejuvenation and more.

All of these procedures injure the skin, sometimes to the deeper layers.

Experts recommend to use Ragozina during and following the course of therapeutic treatments, as it has:

  • regenerating,
  • antimicrobial,
  • moisturizing,
  • anti-inflammatory,
  • antimicrobial activity.

Official clinical studies have been.

They are very expensive. Given that the drug does not cause side effects that would not pass for a couple of days to spend fabulous sums on the evidence so irrefutable does not make sense. After the pharmaceutical company will undertake the study, the price of the drug will increase significantly.

Cosmetologists are convinced that Regeln is quite effective for wrinkles.

This is due to the zinc hyaluronate, which is an associate from the interaction of sodium hyaluronate and zinc chloride.

Hyaluronate is represented by hyaluronic acid — the most popular substance in the practice of any cosmetologist.

Hyaluronic acid maintains skin tone and elasticity (for more details, see «What is affected»).

Hyaluronic acid is practically not absorbed from the skin surface. The mechanism of «rejuvenation» lies in the stimulation of cells that produce the acid is endogenous.

Also «smoothing» of wrinkles promotes entraps a significant amount of water in the skin. But this effect only works during the application.

The only issue on which divergent opinions cosmetologists, is the duration of the course application. Some say that the drug can be used years, almost a lifetime. Others are inclined to the opinion that it is necessary to do a course with breaks for a certain time, giving the skin a «rest».

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Sane person, before using any substances that you consult with a specialist about the effectiveness of the drug in the specific case and the duration of use.

Should consult a dermatologist who is certified beautician to get professional help.

General information

Overdose: there have been no cases of overdose.

Manufacturer: OOO «Dionis» by order of «Pharmaceutical Technology». The Country Of Russia.

Packaging: the gel in tubes of 15 grams.

Shelf life: 2 years from the date of issue of the drug.

Storage conditions: store at temperatures up to 20º C in the dark, out of reach of children.

Category home away from home: without a prescription.

In conclusion, we can say that Regeln will help those who have possible methods of stimulation of regeneration and not disturbed metabolism. These indicators will determine the effectiveness. The drug is widely available. Effective in the treatment of acne. Definitely improves skin tone and elasticity, normalizes sebum production, but the effect may be temporary.

Those who Regeln not helped to deal with wrinkles, contact your specialist.

Photo: Before and after