Bilirubin: normal men blood

Evaluation of bilirubin in the blood of the men gives the opportunity to diagnose a significant number of different diseases, primarily associated with the liver, biliary tract and blood system. For the diagnosis of possible pathology the obtained results of biochemical studies of blood compared to normal rates.

What is bilirubin and its types

Bilirubin refers to the pigment of organic compounds. It is the product of the exchange hemodinamic proteins, primarily hemoglobin (contained in red blood cells) and myoglobin (muscle component), is responsible for transporting oxygen and carbon dioxide. Largely this compound is formed after the physiological death of red blood cells (average life span is 90 – 120 days) in the sinuses of the spleen. It then enters the blood which enters the liver, where it joins with glucuronic acid and then excreted with bile into the intestine. Depending on the stage of an exchange of bilirubin in the body allocate some of its fractions in the blood:

  • Indirect fraction – insoluble component which is formed directly after the death of red blood cells, mainly in the spleen. In the serum is associated with the protein status, which is transported to the liver. This fraction is free to pass through the cytoplasmic membrane into cells, it is toxic, especially for neurocytol (cells of the nervous system).
  • Video fraction – soluble component, is formed in the hepatocytes (liver cells) due to biochemical binding of indirect bilirubin with glucuronic acid and then excreted in the bile. Part of this fraction enters the bloodstream from hepatocytes.
  • Total bilirubin – a measure of concentration of all species of the compound in the serum.
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In clinical practice are usually determined all the factions of this compound that can more accurately diagnose the type, severity and localization of the pathological process.

What is the normal bilirubin?

Despite the fact that bilirubin is a product of decay (recycling) hemodinamic proteins and is subject to removal from the body, a small amount of it is constantly present in the serum, this concentration is its normal rate. Each fraction in the serum of men is represented by its normal rates:

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  • Common fraction – the concentration varies from 3.5 to 20.5 µmol/l (micromol to 1 liter of blood).
  • Indirect fraction – not more than 19.0 mol/L.
  • Video faction to 8.0 mmol/L.

In General, for ease of decoding analysis takes into account the fact that the ratio of indirect and direct bilirubin is 80% to 20%.
Билирубин: норма у мужчин в крови

The norm in men depending on age

The normal concentration of total bilirubin and its fractions is variable and depends on age. The main changes are normal values for a man’s life can be represented in the form of a table:

Total fraction (µmol/l)

Indirect fraction (µmol/l)

Video fraction (µmol/l)

1 – 2 a day in the life

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25 – 190

23,5 – 180

0,5 – 10

3 – 6 day of life

28 – 210

27 – 197

1 – 12,5

The age of the month

3,5 – 20,4

Not more than 16.5

To 5.1

Adult male

3,5 – 20,5

Not more than 19,0

To 8.0

Table for age shows that the highest normal level of total bilirubin in the age of 1 month that is associated with increased physiological destruction of red blood cells in the body of the child. These values in the future (in adults and children older than 1 month) indicate the development of pathology of blood system or structures of the hepatobiliary tract.

How is?

The bilirubin concentration is determined in blood serum in the course of its biochemical studies. To do this, blood is taken from veins with a syringe (usually taken from the cubital vein 5 – 10 ml of blood) to medical staff in terms of handling Cabinet with observance of rules of asepsis (measures to prevent human infection during the execution of medical procedures).

An important condition for obtaining qualitative results of the study is its holding on an empty stomach. Also the night before the test the man should not take fried, fatty foods and alcohol. In the course of biochemical research in addition to the fractions of bilirubin is usually also determined by other indicators, which include creatinine, liver enzymes (ALT, AST, alkaline phosphatase), electrolytes. Determination of bilirubin and enzymes of the liver cells may be performed separately, such an analysis is called liver function tests.

The causes of changes in normal concentration

The decrease in the concentration of this pigment compound is usually has no practical diagnostic value. Increasing the level of fractions of bilirubin accompanied by the development of jaundice (bilirubin stains the skin and the sclera of eye in yellow), which indicates a number of pathological processes, which include:

  • Different pathology of the liver (viral, toxic hepatitis, cirrhosis, fatty liver, congenital diseases, including Gilbert’s syndrome) – in this case increasingly increased direct fraction, indicating its release into the blood from damaged hepatocytes (liver parenchymal or jaundice).
  • Diseases of the biliary tract, which affect the flow of bile (cholelithiasis, tumours, parasitic diseases with the localization of helminths in the structures of the hepatobiliary system) – can cause direct absorption fraction in the blood (obstructive or obstructive jaundice) of bile.
  • Pathology of the blood system and bone marrow, accompanied by an increased destruction of red blood cells (hemolytic, sickle cell anemia, malaria) – leads to increase in indirect fraction (suprarenal jaundice).

The definition of this indicator allows to define a number of pathologic processes in men. To establish the exact causes of their development the doctor is required to appoint and other research methods.