The average content of hemoglobin in the erythrocyte
The average content of hemoglobin in the erythrocyte is a laboratory measurement that indicates the concentration of hemoglobin in the average erythrocyte. In English, this indicator is referred to as the MCH (mean corpuscular hemoglobin). MSN is used to determine the type, cause and severity of anemia.
What is the red blood cells and hemoglobin?
Erythrocytes – these are the basic blood cells, which contain hemoglobin. Hemoglobin (Hb) is a molecule inside red blood cells, consisting of iron and protein that carries oxygen from the lungs to the body cells. Also Hb in red blood cells deliver carbon dioxide from the cells to the lungs, after which it is excreted from the body.
How to calculate the average content of Hb in the erythrocyte?
MCH is calculated by dividing the total amount of hemoglobin (g/l) by the total number of red blood cells (millions per microliter).
What level of MCH is normal?
The normal rate in adult MCH is 27 to 33 picogram in one erythrocyte. Always remember that normal values may vary depending on the equipment of the laboratory in which the indicator is determined MCH. Therefore, to interpret the results of the tests need to use the specified laboratory standards.
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Who conducted this analysis?
Indicator MCH is included in the General analysis of blood, which is assigned for many reasons – from routine screening to detect the disease or toxic effects. Laboratory tests may be used to determine the improvement or deterioration of the disease, determine the success or ineffectiveness of the treatment. For example, the indicator MCH used in the diagnosis of hereditary spherocytosis.
What is hereditary spherocytosis?
Hereditary spherocytosis is a genetic disease of red blood cells in which these cells develops a defect in their outer membrane, so that they acquire a spheroidal shape. In some people, the disease does not cause severe symptoms, and its usually not detected. Others observed serious anemia, which may need regular blood transfusions. Some patients may need removal of the spleen.
What is the meaning of MCH indicator for diagnosis of anemia?
Anemia is a decrease in the number of red blood cells and hemoglobin. In terms of its MCH divided into three groups:
- Hypochromic anemia MCH less than 26.
- Normochromic anemia MCH within 27 – 33.
- Hyperchromic anemia – MCH above 34.
What can be the reason for the increase in MCH?
Basically if MCH above 34, it is considered high. The main reason for this increase is macrocytic anemia. Macrocytic anemia is a blood disease in which is produced an insufficient number of red blood cells, but each of these cells contains more hemoglobin. This disease is often caused by lack of vitamin B12 or folic acid in the body. Also increase MCH may occur with chemotherapy.
What can cause lower MCH?
If the average content of Hb is less than 26, it is believed that it is lowered. The MCH level can be reduced after blood loss due to iron deficiency or with microcytic anemia. Microcytic anemia is a disease in which the blood contains red blood cells is pathologically small. The smaller size of these cells, the smaller the amount of hemoglobin they contain. Microcytic anemia is often caused by iron deficiency, which can be a consequence of its lack in diet, blood loss or violation of its assimilation, storage and use in the body. Lowering MCH may be caused by hemoglobinopathies is a group of diseases characterized by changes in the structure of hemoglobin.
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How is the analysis conducted?
MCH is part of a normal blood count. After the puncture of the vein the blood is taken in a tube containing anticoagulant, to prevent clotting. A small sample is analyzed on laboratory equipment, which counts the number of red blood cells, defined by their size. Then measure the amount of hemoglobin in these cells. This is followed by a mathematical calculation MCH. In addition, the technician can make a blood smear, stain it and examine under the microscope. He can visually evaluate the color of red blood cells, which is directly related to the amount of hemoglobin in each of them.
The value of the MCH can not change quickly, the body needs a few days to produce the red blood cells of different sizes. This indicator can change suddenly, if the patient spent a blood transfusion. If a transfusion is not performed, these changes may arouse suspicion error, so you should retest it.