Autoimmune urticaria: treatment and prevention

Hello, dear readers. Many of you have heard or encountered such skin disease like hives. This disease has several types, depending on the severity and extent of development.

Today we take a closer look at the causes, symptoms of autoimmune urticaria and methods of its treatment in clinical practice.

What is an autoimmune urticaria?

Аутоиммунная крапивница: лечение болезни и профилактикаIs called autoimmune disease in which the degeneration of cells damage and attack healthy cells, causing inflammation.

Most often this disease caused by disorders of the immune function of the body, which decreases the activity of one group of lymphocytes, which does not allow the attack on its own healthy cells. That is essentially cells wrestle with their own antibodies, and is not pathogenic.

Autoimmune urticaria, as well as other types of the disease, manifested as a rash all over the body, sometimes with blisters, which in appearance resemble a burn from a nettle.


Аутоиммунная крапивница: лечение болезни и профилактикаWhy does this disease? As a rule, the development of the disease contribute to:

  • Pathology of the endocrine system (ovarian dysfunction, diabetes mellitus, hyperthyroidism, hypothyroidism);
  • Viral and fungal infections;
  • Serum sickness;
  • Different types of tumor.
  • Other autoimmune diseases (rheumatoid arthritis, lupus erythematosus);
  • Disproprotionate;
  • Frequent intake of food additives (emulsifiers, preservatives, dyes).


Аутоиммунная крапивница: лечение болезни и профилактикаThe clinical picture of autoimmune chronic urticaria is similar to. Body sudden rash and blisters red colour, which slightly rise above the surface of the skin.

The appearance of the rash contributes to some physical or chemical influence which gave impetus to the maximum blood concentration of histamine.

Eruptions are accompanied by local swelling and itching, and the blisters in contact quite painful. While acute urticaria is after a couple of days, weeks or autoimmune chronic disease can last for months, years with periodic exacerbations.

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The patient often feels weak, headache, may occur angioedema and even anaphylactic shock.

If you look at the photo below, you’ll see what it looks like chronic urticaria on the human body in the period of exacerbation.

Diagnosis of the disease

Аутоиммунная крапивница: лечение болезни и профилактикаTo determine the allergic reactions of an autoimmune nature, you should visit a dermatologist, who, in turn, will conduct a special test with the use of autoserum. It is a screening method (intradermal test).

If the dose of histamine in the sample is equal to 10 mg/ml, then the result is positive. When diagnosing diseases the immunological reaction is carried out after 15 and 40 minutes. As a rule, positive results were observed in 25-40 % of cases.

This method of detection of disease if a positive result will give the doctor the authority for further treatment. In addition, you can not pass other tests, as will be known to cause rash.

Remember, these tests are conducted exclusively by allergists or dermatologists. A week before the test you have to refrain from taking a variety of hormonal drugs, and in five days from receiving histamine medicines.

If the result is positive: if the diagnosis is confirmed, do not despair. Treatment of autoimmune urticaria a time-consuming and long process.

Аутоиммунная крапивница: лечение болезни и профилактикаHow to treat such a disease? In fact, the principle of treatment of this disease does not differ from the treatment of ordinary urticaria.

Initially set the factors that gave impetus to the spread of the rash. It is usually, thermal effects, allergic to food or external stimuli, stress, infectious diseases and others.

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Then the doctor prescribes antihistamines and, if necessary, glucocorticosteroid drugs (during exacerbation of the urticaria). In addition, you will be prescribed a cream or gel for relief of local symptoms (inflammation, itching).

Together with the above treatment it is necessary to identify the root cause of the disease and to begin to deal with it by taking antiviral, antibacterial, antifungal agents.

If you have suffered chronic hives, you need to follow a diet, avoid stressful situations, to exclude allergens and to protect themselves from all sorts of pathogens.

What else can we treat the disease? If the prescribed treatment did not bring the desired effect, or place of frequent exacerbations in the form of angioedema or asphyxia, that patients with urticaria are advised to undergo hospitalization or to start treatment the following means:

  • Drugs that artificially depress immunity. These include, for example, cyclosporine. It blocks the subsequent production of autoantibodies.
  • Therapeutic plasmapheresis. This procedure is used to clean the blood from degenerated cells and antibodies. Now gaining popularity of this treatment, as criaturas.
  • Injection of immunoglobulin, which are designed to deal with immune inflammation.

Аутоиммунная крапивница: лечение болезни и профилактикаTo prevent future exacerbations doctors can be applied hyposensitization or a different induction of tolerance.

This procedure involves the input of minimal doses of allergen. Gradually the intake increased. This makes it possible to ensure that the patient’s immune system will begin to accept foreign cells as their own and cease to deal with them.

The skin can be affected also heat, cold and sunlight, which is achieved due to indifference on the trigger.

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If the appearance of urticaria was affected by chemical exposure, you may wish to change of activity of the patient.

Unfortunately, autoimmune urticaria is very difficult treated. Not all drugs are effective and relieve symptoms in the short term.

Corticosteroids can not be long to take, otherwise it can cause various health problems. Usually patients with chronic urticaria largely restrict themselves, giving rise to the histamine in the blood.

If the doctor can identify the cause of the disease (which is of immune nature, not allergic), only in this case will be assigned to the correct treatment that will help you to get rid of the rash and blisters. Be healthy!

Author: Anna Derbeneva (dermatologist)