Barrett’s esophagus: what is it, causes of disease
Barrett’s esophagus — what is it?
Very often diseases of the digestive system are the result of neglect or improper treatment of existing chronic processes. Timely intake of small prophylactic doses of drugs and diet could save one from the adverse effects. But people rarely think about such need, and as a result of illness not just often aggravated, but complications arise, get rid of them is almost impossible.
One such disease — Barrett’s esophagus. What is it and why is it there? Needless to panic, if after another survey put this diagnosis?
A little anatomy
Coordinated work of all organs of the digestive system cause not only their function but also in structure. One of the leading roles is a mucous membrane — epithelium. Is that layer, which is located on the border of the esophagus and the environment (in this case, it’s food, drugs and liquids).
The epithelium, in spite of one origin, depending on the location in the internal organs, has features in the structure. In the esophagus it is multi-layered, flat neorogovevayuschy. This is an ideal protection authority. In response to a regular stream of different quality and composition of the products of the mucous layer on not only damaged but capable of rapid recovery (due to the basal layer of the epithelium).
When developing Barrett’s esophagus in it there are areas of intestinal metaplasia. That is such a strange term? This occurrence sites atypical for this body of cylindrical epithelium. It is more characteristic of the intestine, hence the name.
Causes of Barrett’s esophagus
Still not installed for some reason, there is degeneration of normal protective epithelial layer of the esophagus at the warped atypical. But it is known that one of the predisposing factors in the development of diseases are some disease processes of the esophagus. That leads to the development of Barrett’s esophagus?
- Pathological heartburn from gastroesophageal reflux (regurgitation of gastric contents due to weakness in the lower esophageal sphincter). In this pathology increases the production of hydrochloric acid which affects the body. Long GERD leads to Barrett’s esophagus, is the main reason. According to statistics, 10-20% of sufferers reflux disease people over time there is degeneration of the cells of the mucosa. This kind of «protective» reaction on aggressive factor due to the fact that columnar epithelium is more resistant to outdoor conditions.
- Constant use of certain chemical medicines, oppressive work of stratified squamous epithelium, which include: «Methotrexate», «Cyclophosphamide».
- Barrett’s esophagus happens in children, but it is a rare pathology and it is due to genetic predisposition or impaired process of cell differentiation during fetal development.
Why this disease pay so much attention doctors? It refers to precancerous processes and is often found in those patients who irregularly or improperly treated GERD, esophagitis, there was a doctor in connection with these chronic illnesses from case to case, preferring to tolerate years of frequent heartburn.
Interesting facts about Barrett’s esophagus
The nominal name of the disease — Barrett’s esophagus, give the name of the author, who discovered it. Thus, it is assumed. But not in this case! In 1950, the surgeon Norman Barrett claimed in his report that the esophagus cannot be removed by columnar epithelium. So the title is rather ironic, as a reminder to the surgeon of his delusion.
Barrett’s esophagus is a complication of many diseases of this Department of digestive system: reflux disease, esophagitis. About 1% of people in the world tend to its development.
One of the leading symptoms of these disease processes, leading to Barrett’s esophagus — a long and painful heartburn. But not all diseases accompanied by heartburn, will lead to intestinal metaplasia. Burning sensation behind the breastbone must be the result of the influence of the acidic environment of the stomach to the lower esophagus (in the norm of the environment slightly alkaline). Burning pain should be disturbed of a man at least five years — is one of the conditions of occurrence of the disease.
The people who test the areas of intestinal metaplasia in the esophagus, prone to:
The disease progresses very slowly, and with the full treatment and regular follow-up can permanently stay on the stage of development at which it was detected.
Barrett’s esophagus, what is this, another mystery of the digestive system or the result of running a person’s relationship to their health? Yes, many of the facts in the development of this disease scientists to install yet. But it is clear that often the disease can appear like a advanced case of GERD or esophagus. This is a reminder to all that sometimes it is better to prevent disease than to cure it.