Difluzol — usage instructions

Currently, one of the most common antimicrobial agents are medicines, which include the main active substance fluconazole. These drugs Difluzol apply, application instructions is presented in the article.

Pharmacological action

Clinical studies of the drug it was established that the application of Difluzol the bioavailability of the active substance is 90%. Absorption occurs mainly in the intestine. But, due to the fact that the body of the company full vyvodyaschy matter is almost 25 – 30 hours, during this time, fluconazole penetrates actively into all tissues of the human body. This fact made the drug easy to use, just one capsule maximum dosage for getting positive result.

The effect of the drug is oppressive biosynthesis of sterols, while possessing a highly selective capacity for a large number of microorganisms Candida parapsilosis, Candida neoformans, Candida albicans and Candida tropicalis.

Fluconazole exhibits in relation to fungal enzymes is very high specificity than has an effect at low doses.

Distinguishing the facts of pharmacokinetics in older patients

The study of the action of Fluconazole involved patients aged 60 years and older, which, when combined with Difluzol took diuretics to reduce the pressure. The results of the blood work of these patients showed that the maximum concentration of the basic substance reached a peak in the blood through a 1.0 – 1.3 hours after start of treatment, the average half-life was slightly increased than that of normal patients and from 46 – 48 hours. The reason is likely that in elderly patients the renal excretory function is running more slowly than younger adults.

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Indications for use

Difluzol is used for the treatment and prevention of many diseases of a fungal nature.

In adult patients, the drug is used to treat the following diseases:

  • Cryptococcal meningitis (treatment and prevention in patients with a high probability of risk of disease);
  • Invasive candidiasis;
  • Candidiasis oropharyngeal, and cutaneous-mucous character;
  • Atrophic candidiasis of oral cavity, arising due to non-compliance hygienic cleaning by using dental prostheses;
  • Acute vaginal candidiasis, if similar drugs are not brought the desired effect;
  • Pityriasis versicolor, dermatophyte individual parts of the body, the ringworm;
  • Onychomycosis nail plate.

To prevent Difluzol used with all of the above diseases in HIV-infected patients, patients with disease incidence more than four times a year in patients with malignant tumors after radiation treatment and chemotherapy.

The drug is allowed for treatment and prevention of diseases types of candidiasis in patients who are immunocompromised and in intensive therapy to prevent relapse of cryptococcal meningitis.

Difluzol contraindicated for people with increased susceptibility to the active ingredient (Fluconazole) and other ingredients of the drug.

As part in the production of the drug enters the milk sugar (lactose monohydrate) not recommended for patients with individual intolerance.

Difluzol capsules is contraindicated in children under 3 years.

With care taken to patients with impaired functions of kidney, liver, and organic diseases of the heart muscle. This limitation is due to the fact that fluconazole disrupts the electrolyte balance and the patient may be a risk factor proaritmicski state.

When applying the Fluconazole clinic shows that a substance found in breast milk, so Difluzol contraindicated for breastfeeding women.

How to use medicine?

Difluzol applied depending on its dosage form and dosage.

There are three dosage forms: encapsulated Difluzol, tablets, coated tablets and as a sterile solution for the preparation of infusions. Tablets and capsules are produced with dosages of 50, 100 and 150 mg, solution 2 mg per 1 ml.

Day the dosage depends on the severity of fungal diseases. The treatment lasts until the results of tests on crops does not show a complete absence of growth of fungus.

When cryptococcal infection and meningitis in the first day of the one-off treatment to get 400 mg, then treatment is continued, taking from 100 to 400 mg per day. The whole period a full cure can reach seven to eight weeks.

When fungal infections of various etiologies the treatment is cyclical with the use of a single dose of 150 to 800 mg once per week. Treatment continued for 1 – 3 weeks depending on the development of the clinical picture.

In vaginal candidiasis, the dose may be one-time, up to 300 mg, and three cycles with intervals of two days. For each receiving application Difluzol not more than 150 mg.

Recommended by doctors dose in onychomycosis of the nail plate of 150 mg (one capsule) 1 times a week. The duration of rehabilitation treatment is directly dependent on the rate of growth of uninfected healthy nail fungus.

Side effects

In clinical studies of the drug, and based on feedback from the nervous system were observed dizziness, fainting and headaches in relation to digestive tract acute abdominal pain, night nausea and retching, constipation. Some patients experienced allergic skin reactions in the form of small rash, urticaria.

People with chronic diseases of musculoskeletal system aggravates diseases of the joints, sometimes developed myalgia. There were General signs of illness: fever, sweating and fatigue, weakness, anaemia.

Overdose antimicrobials was recorded only once in an HIV-infected patient. His condition returned to normal after gastric lavage.

Use with other drugs

Difluzol is contraindicated simultaneous reception with drugs:

  • Cisapride;
  • Erythromycin;
  • Astemizole;
  • Pimozide;
  • Amiodarone;
  • Quinidine.

Drugs affecting the pharmacological action of Fluconazole:

  • Hydrochlorothiazide;
  • Rifampicin.

Drugs, the activity of which is influenced by fluconazole:

  • Amitriptyline;
  • Azithromycin;
  • Carbamazepine;
  • Cyclosporine;
  • Medications-calcium channel blockers;
  • Losartan;
  • Nonsteroidal anti-inflammatory drugs;
  • Oral contraceptives;
  • Rifabutin.

Special instructions

Difluzol immediately to cancel in cases of hepatotoxicity, disorders of the indicators of the functioning of the liver and kidneys, in anaphylactic reactions, with signs of toxic epidermal necrolysis, as well as in cardiac arrhythmias.

As in applying the drug may dizziness and convulsions, control of the vehicle should refrain during treatment.

Important information! Before applying Difluzol mandatory consultation of the doctor. Do not forget that the uncontrolled use of drugs can lead to the development of other diseases.