Combigan eye drops: manual, price, reviews, analogs

Combigan protivoglaucomny is a combined tool to reduce pressure inside the eye.

Pharmacological action

Комбиган глазные капли: инструкция, цена, отзывы, аналогиThanks to the combined action of two main components Combigan (brimonidine and timolol), which reinforce the effect of each other, decreasing the pressure inside the eye. The brimonidin is an adrenomimetic which stimulates α2 — adrenoreceptor, and timolol is a blocker of β-adrenergic receptors. Their mutual influence provokes a stronger hypotensive effect than if these substances were applied separately. Components of the drug comes in small amounts into the bloodstream. However, this may be accompanied by side effects.

The composition and form of issue

Available in drops for the eyes, a solution which is transparent and sterile. Go drops vial, the volume of which is 3 and 5 ml. the Main components of the tools are brimonidine tartrate and timolol maleate. Auxiliary speakers – benzalkonium chloride, hydrogen phosphate, heptahydrate sodium dihydrogen phosphate monohydrate sodium, sodium hydroxide, water.

Indications for use

Used for the treatment of intraocular hypertension and open-angle glaucoma. Also these drops are recommended when the lack of effectiveness of β-adrenergic blocker topical application. To appoint Combigan needs eye doctor who will first establish the correct diagnosis and then determine therapy.

Method of application

Комбиган глазные капли: инструкция, цена, отзывы, аналогиThe drops are used for adults, including elderly patients. The eye instilled with 1 drop 2 times a day. Before meals should be a break in 12 hours. The procedure is performed in the morning and the evening. To reduce the risk of system penetration of the drug, necessary after instillation press the inner corner of the eye or to close the eyelids.

If the doctor prescribes together with the tool and other eye drops, it should only be used 5 minutes after the previous instillation.

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You cannot use Combigan at:

  • obstructive lung disease in a heavy form;
  • antidepressant therapies;
  • pregnancy and breast-feeding;
  • hypersensitivity to the active substances drops;
  • heart failure;
  • airway hyperresponsiveness;
  • sinus bradycardia;
  • children under 18 years of age.

Side effects

Комбиган глазные капли: инструкция, цена, отзывы, аналогиDuring use Combigan you may experience side effects of local character. These include:

  • cramps and dryness in the eyes;
  • redness of the conjunctiva;
  • impaired vision;
  • allergic manifestations;
  • the increased discharge of tears;
  • fear of the light;
  • point keratitis;
  • edema of the cornea.

Possible and system-wide side effects:

  • dizziness;
  • dry mouth and nose;
  • palpitation of the heart;
  • various disorders arising in the CNS;
  • a change of taste;
  • rhinitis;
  • pain in the head;
  • drowsiness;
  • increase in blood pressure;
  • allergic dermatitis.


When you use topically in doses exceeding recommended, possible decrease in blood pressure, occurrence of seizures, fever, apnea, bronchospasm, dizziness, pain in the head, cardiac arrest. In case of accidental intake of the solution inside may confused consciousness, should be suppressed by the Central nervous system, decrease AD, to increase the body temperature. In this case, you should immediately hospitalize the person who took these drops inside. In the hospital this patient washed stomach and appoint the administration of activated charcoal. When local overdose require symptomatic treatment.

Interaction with other drugs

Комбиган глазные капли: инструкция, цена, отзывы, аналогиResearch on the use Combigan with other drugs not specifically been conducted. But you can’t use along with MAO inhibitors. Caution need to use these drops along with drugs affecting metabolism. May increase the impact of funds that suppress the Central nervous system, when used with this drug.

Timolol in combination with anesthetics is able to increase HELL. You cannot use it with epinephrine as it may develop mydriasis. The contents of timolol in the blood increase cimetidine, ethanol, hydralazine. Drops especially carefully it is necessary to apply with drugs that lower BP.

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Special instructions

Комбиган глазные капли: инструкция, цена, отзывы, аналогиBefore burying the tools you need to remove the lenses and set them back 15 minutes later. This is due to the fact that it contains benzalkonium chloride which may cause the lenses in a state of disrepair. Also this component can cause irritation of the organ of vision. Do not touch tip of bottle to any surface to avoid contamination of the solution and re-infection of cured eyes.

Since the active ingredients penetrate into breast milk, it is impossible to apply these drops breastfeeding. But if the doctor recommends the use of the tool, during treatment it is necessary to abandon breastfeeding. Combigan used in pregnant women only when the anticipated effect is expected more than the risk for normal development of the fetus.

As Combigan may cause drowsiness, blurred vision, weakness, during treatment, they should refrain from driving or operating mechanisms that require attention.

Important! If after treatment have an allergic reaction and all sorts of other side effects, it is necessary to cancel his appointment and to consult an ophthalmologist.

In patients who have severe disturbances in work of kidneys, timolol may cause decrease in blood pressure. In patients with anaphylactic reactions to this drug may decrease the effectiveness of the introduction of epinephrine. that is assigned in the usual dosage.

If the doctor determines that Combigan you want to stop using, then this should be done gradually. Otherwise, it may cause various disorders in the functioning of the heart may occur infarction, and even sudden death occur.

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Opened vial is recommended to use for 1 month. Keep the preparation you need in a dark place and away from children.


Alexander, 44

«Komihana a terrible drip. When I used half of the medicine dropper at the same time started to pass a few drops. Under the lid of the vial the medicine becomes the crystals and enters upon instillation in the eye. How many use eye drops, but they are not satisfied.»

Marina, 35 years

«A great medication for relieving intraocular pressure. You can only apply after 18 years. Combigan has many side effects and contraindications. Overdose terrible consequences. I think that this drug is more crippling than cure. There are more secure means».


Комбиган глазные капли: инструкция, цена, отзывы, аналогиAnalogues data drops are:

  • Cosopt;
  • Drops fotil;
  • Pilocarpine;
  • Xalatan;
  • Azarga;
  • Betoptic;
  • Travatan;
  • Trusopt;
  • Timolol.

To prescribe a similar drug needs a doctor-ophthalmologist, who needs to follow for obtaining the desired effect from taking eye drops. It is not recommended to change drops prescribed by the doctor for the same.


The cost of this drug at pharmacies in Russia ranges from 570 to 650 rubles.