Gout in men and women: causes, symptoms and treatment of this disease
How to spot gout at different stages: symptoms and treatment
The development of gout is due to metabolic disorders, in which the salt of uric acid (aka – sodium urat) are deposited as crystals in joints and soft tissues.
This chronic condition is known from ancient times and were once called the «disease of kings», as the prerequisites of its development was a surfeit of food and alcoholic beverages.
Today, gout is quite rare – 3 people out of a thousand.
The most common symptoms of gout occur in males about 95% of the most vulnerable under the age of 40. In women, the symptoms of gout are rare and may occur after menopause.
Be gout can any joints: from fingers to toes.
Although it is considered a disease of the joints, the defeat affects a number of tissues and organs and causes serious enough harm to the human body.
The causes of the disease
The underlying cause of gout –high, does not reduce the level of uric acid in the blood.
As a result of its derivatives – monosodium urate crystals – are deposited in the organs, soft tissues, joints and other systems. Eventually the joint begins to break down.
Among the prerequisites to the accumulation in the body uric acid can name two:
- kidneys can not cope with the large-scale accumulation of uric acid;
- uric acid is produced in standard quantities, but the kidneys are not able to overcome it.
Pathology develops under the influence of certain factors, usually related to a metabolic disorder of purine bases (nucleotides) and a delay of uric acid in the body.
The main reasons for the strengthening of the accumulation of uric acid are:
- increased intake of purine bases (in particular, unlimited consumption of fatty fish, meat, alcohol, etc.);
- the decrease in the number of output of uric acid;
- the increased catabolism of purine nucleotides.
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Genetic predisposition implies the presence of various enzymopathies, i.e. diseases that lead to reduced number in the body of certain enzymes.
Especially in cases when they are essential for the proper metabolism of purine bases.
Increased intake of purine bases
Doing a substantial amount of the purine base transformirovalsya, including the formation of uric acid, the result of what the kidneys do not have time to clean up from her body.
Most urinoterapii products:
- meat and meat by-products;
- oily fish;
- concentrated broths;
- cooking fats;
Of course, not necessarily the use of these products will lead to gout, but under certain conditions they can create a favorable environment for its development.
The reduction in the amount excreted in the urine uric acid
Usually this situation is typical for people with chronic kidney disease.
In these cases, gout acts as a consequence of the primary disease, by eliminating that, you can cope with the unpleasant consequences.
The increased catabolism of purine nucleotides
Catabolism involves the breakdown complex compounds into simple.
Against gout is the catabolism of purine bases, leading to the formation of uric acid.
The reason for this can serve not only food, but directly to the body, as every cell of a person contains a purine base. When a cell «dies», they enter the bloodstream and disintegrate.
The increased catabolism of purine nucleotides may be temporary in nature, and may be the result of severe diseases of a chronic nature.
As examples of the causes of enhanced catabolism of purine nucleotides include the following:
- receiving picostation (drugs to stop the growth of new cells);
- hemolysis (destruction of red blood cells), etc.
What is the disease?
Symptom of gout is a standard attack of gouty arthritis, i.e. there is the inflammation of one of the joints, manifested as swelling, severe pain, fever and redness of the skin in the area of inflammation.
Most often, seizures are the morning or night temporary lasting from 2 to 7 days. Relapses can occur with involvement of other joints, resulting in the destruction of the diseased joint.
The main symptoms of gout:
- when diseases appear peculiar growths (also known as «tophi»);
- also a significantly increased level of uric acid in the body.
If the tophus burst, you will see the bright crystals of uric acid. Since education is perceived by the body as a foreign body, in areas of education of nodes, the accumulation of leukocytes and inflammation, called «gouty arthritis».
Gout often in the kidney the stones are formed, leading to kidney failure and then death.
Specific signs and symptoms are inextricably linked with the stage of gout.
The first stage of premorbid
At this stage, the disease has these symptoms:
- itching of the skin;
- predisposition to diseases of the gastrointestinal tract;
- the increase in body weight.
This stage is characterized by acute attacks.
Chronic stage is the most unpleasant
If the disease becomes chronic, the symptoms begin to manifest in all systems of the body:
- the formation of tophi;
- the development of kidney stones;
- severe redness of the skin;
- limitation of joint mobility and other characteristics.
The complex of therapeutic measures
Therefore, when the first signs of gout you should immediately begin treatment to prevent the transition of the disease into the chronic stage.
For therapeutic purposes requires an integrated approach involving the identification and impact of abnormal chain, i.e. medical experts to determine the root cause of disease and prescribe appropriate treatment.
However, note that in some cases (for example, fermentopathy) treatment is symptomatic.
Gout treatment encompasses the following methods:
- taking anti-inflammatory means;
- use protivopodagricakih drugs;
- application of methods of local treatment;
- the use of traditional medicine.
Thus, if a family has a case of gout, should be wary to stick to a healthy lifestyle and proper nutrition, as well as periodic screenings, monitoring the level of uric acid in the blood.
Crucial preventive tool for development of gout – limiting the intake of foods rich in purines.