Seronegative rheumatoid arthritis

The group of abnormalities relates seronegative rheumatoid arthritis. The disease is caused by the progression of autoimmune processes in the body. Expanded form of disease is accompanied by severe inflammation that affects the joint and its shell.

The presence of antibodies contributing to joint destruction, are not always sufficient for the manifestation of the disease. In medical practice there were cases, when seronegative rheumatoid arthritis occurred without the development of antibodies. Experts interpret this phenomenon as a genetic anomaly. The exact reasons of development of a pathology it is not revealed.

Серонегативный ревматоидный артрит


Features of the disease

Seronegative arthritis is difficult to treat. Conservative therapy can halt the progression of the disease. A person suffering from inflammatory involvement of the joints, must continuously use the medication. When choosing the optimal treatment strategy, takes into account the stage, the clinical manifestations and the individual characteristics of the organism.

Serous arthritis is a complex lesions of the joints due to disturbance of protein metabolism. Its distinguishing feature is the lack of rheumatoid factor in serum. The disease is considered common, the increasing number of victims. Insidious pathology is the inability to cure her.

There are several main stages of disease:

  • periarticular osteoporosis;
  • the narrowing of the connecting gap;
  • erosion of the bones;
  • arthropathy and ankylosis cartilage.

Another form of the disease is seropositive rheumatoid arthritis. Its development is caused by the penetration into the body of viruses and bacteria. The disease occurs more frequently in people of age, this is due to the deterioration of the joints. In this case, the treatment is supportive in nature.

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The antibodies produced in pathology and take an active part in the process of formation of hypodermic nodes and articular lesions. This adversely affects the overall health of the person and affects his life activity. This condition is characterized by seronegative syndrome.

Seropositive rheumatoid arthritis leads to damage to the joint due to the penetration into its cavity pathogenic bacteria.


The development of the pathology and its manifestations

Not to be confused with seropositive and seronegative form of the disease. The first type of pathology identified in the ICD 10 code M05. Seronegative form of the disease is included in another category. In the international classification, ICD-10, it is designated M06.

Disease Symptoms .
Seropositive rheumatoid arthritis. It has several distinctive features. Onset of the disease is characterized by weakly pronounced over. Seronegative stage is characterised by an acute sudden manifestations. The person feels weakness and General malaise. Possible increase in body temperature that is constantly changing. On the background of anemia, you may notice swollen lymph nodes. There is atrophy of the muscles. Seropositive arthritis affects several joints asymmetrically. The negative impact of exposed knee joints. Gradually, the process focuses on the feet and hands. The most vulnerable are the interphalangeal and radiocarpal cartilage.
Seronegative form of the disease. For seronegative forms is characterized by the absence of morning stiffness. A person does not feel unpleasant symptoms upon awakening. He is a marked increase in lymph nodes. Seronegative stage of the disease is asymmetrical vessels with the gradual development of symmetric polyarthritis.
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The risk of pathology is in kidney failure and violation of the functional capacity of the extremities. This disease leads to a limitation of further disability.

Recommended time to begin treatment, this will avoid severe complications.


Diagnostic measures and therapeutic tactics

Серонегативный ревматоидный артрит

On diagnostic procedures and further treatment tactics is affected by the stage of the disease. Standard diagnosis begins with the collection of complaints and examination of the patient. Based on these data, the specialist sends the patient to the passage of the latex test. Through this procedure it is possible to determine the presence or absence of rheumatoid factor. Shall further blood test: to fix the level of erythrocyte sedimentation rate and white blood cells. It allows to reveal the inflammatory process.

Disease treatment begins with medical therapy. Conservative exposure can reduce clinical symptoms and to stop progression of diseases. The treatment is based on the use of immunosupressants and basic medicines. Often the situation is complicated by disorders of protein metabolism. In this case, it is possible to Supplement the standard therapy with intake of D-penicillamine.

Picking up DMARD treatment, a specialist should consider the likelihood of adverse reactions. Standard therapy involves the use of cyclosporine and anti-inflammatory drugs (diclofenac, nimesil). Often treatment involves the use of immunosuppressant-cytotoxic drugs (D-penicillamine).

In addition to receiving prescribed drugs, you can visit a physiotherapy, massage and perform therapeutic exercises. In acute development of the disease the treatment involves surgical intervention. Patients suffering from joint damage, are sent annually to resort.